TOP2B

TOP2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QX3, 4G0U, 4G0V, 4G0W, 4J3N
Identifiers
Aliases	TOP2B, TOPIIB, top2beta, topoisomerase (DNA) II beta, DNA topoisomerase II beta, BILU
External IDs	OMIM: 126431; MGI: 98791; HomoloGene: 134711; GeneCards: TOP2B; OMA:TOP2B - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	25,664,907 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	6,104,584 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; endothelial cell; ; Achilles tendon; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; retinal pigment epithelium; ; epithelium of colon; ; rectum;
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; tail of embryo; ; medial ganglionic eminence; ; genital tubercle; ; thymus; ; abdominal wall; ; dermis; ; condyle; ; lobe of cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; nucleotide binding; DNA binding; histone deacetylase binding; chromatin binding; isomerase activity; metal ion binding; DNA topoisomerase activity; protein C-terminus binding; protein heterodimerization activity; enzyme binding; ATP binding; protein kinase C binding; ribonucleoprotein complex binding;
Cellular component	cytosol; nucleoplasm; heterochromatin; nucleolus; nucleus; cytoplasm; ribonucleoprotein complex; viral integration complex;
Biological process	resolution of meiotic recombination intermediates; axonogenesis; DNA metabolic process; neuron migration; forebrain development; mitotic DNA integrity checkpoint signaling; sister chromatid segregation; DNA topological change; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate;
	Sources:Amigo / QuickGO
Orthologs
	7155
	21974
	ENSG00000077097
	ENSMUSG00000017485
	Q02880
	Q64511
	NM_001068; NM_001330700
	NM_009409
	NP_001059; NP_001317629
	NP_033435
	Wikidata
View/Edit Human	View/Edit Mouse

DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.