TOP3A

TOP3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CGY, 4CHT
Identifiers
Aliases	TOP3A, TOP3, ZGRF7, topoisomerase (DNA) III alpha, DNA topoisomerase III alpha, PEOB5, MGRISCE2
External IDs	OMIM: 601243; MGI: 1197527; HomoloGene: 3394; GeneCards: TOP3A; OMA:TOP3A - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,315,007 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,668,191 bp
RNA expression pattern
	Top expressed in
	blood; ; ganglionic eminence; ; ventricular zone; ; bone marrow cells; ; monocyte; ; stromal cell of endometrium; ; granulocyte; ; tonsil; ; epithelium of colon; ; testicle;
	Top expressed in
	spermatocyte; ; zygote; ; secondary oocyte; ; spermatid; ; tail of embryo; ; primary oocyte; ; Ileal epithelium; ; genital tubercle; ; epiblast; ; seminiferous tubule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA topoisomerase type I (single strand cut, ATP-independent) activity; DNA binding; zinc ion binding; protein binding; isomerase activity; metal ion binding; DNA topoisomerase activity; single-stranded DNA binding; nucleic acid binding;
Cellular component	PML body; nucleoplasm; chromosome; nucleus; mitochondrion; mitochondrial matrix;
Biological process	DNA replication; DNA topological change; meiosis; mitochondrial DNA metabolic process; chromosome separation; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	7156
	21975
	ENSG00000284238; ENSG00000177302
	ENSMUSG00000002814
	Q13472
	O70157
	NM_004618; NM_001320759
	NM_009410
	NP_001307688; NP_004609
	NP_033436
	Wikidata
View/Edit Human	View/Edit Mouse

DNA topoisomerase 3-alpha is an enzyme that in humans is encoded by the TOP3A gene.