TOX

TOX
Identifiers
Aliases	TOX, TOX1, thymocyte selection associated high mobility group box
External IDs	OMIM: 606863; MGI: 2181659; HomoloGene: 8822; GeneCards: TOX; OMA:TOX - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	59,119,147 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	6,991,557 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ventricular zone; ; secondary oocyte; ; thymus; ; ganglionic eminence; ; mucosa of sigmoid colon; ; orbitofrontal cortex; ; muscle layer of sigmoid colon; ; islet of Langerhans; ; dorsolateral prefrontal cortex;
	Top expressed in
	rib; ; thymus; ; medial dorsal nucleus; ; cricoid cartilage; ; female urethra; ; Jacobson's organ; ; medial geniculate nucleus; ; saccule; ; zygote; ; mammillary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	lymphocyte differentiation; positive regulation of natural killer cell differentiation; lymph node development; Peyer's patch development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9760
	252838
	ENSG00000198846
	ENSMUSG00000041272
	O94900
	Q66JW3
	NM_014729
	NM_145711; NM_001377078; NM_001377079
	NP_055544
	NP_663757; NP_001364007; NP_001364008
	Wikidata
View/Edit Human	View/Edit Mouse

Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene. TOX drives T-cell exhaustion and plays a role in innate lymphoid cell development.