TP63

TP63
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4A9Z, 1RG6, 2RMN, 2Y9T, 2Y9U, 3QYM, 3QYN, 3US0, 3US1, 3US2, 3ZY0, 3ZY1
Identifiers
Aliases	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein p63
External IDs	OMIM: 603273; MGI: 1330810; HomoloGene: 31189; GeneCards: TP63; OMA:TP63 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	189,897,276 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	25,710,852 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of hip; ; skin of arm; ; human penis; ; hair follicle; ; vulva; ; gums; ; nipple; ; skin of abdomen; ; gingival epithelium;
	Top expressed in
	hair follicle; ; molar; ; skin of external ear; ; conjunctival fornix; ; skin of back; ; transitional epithelium of urinary bladder; ; corneal stroma; ; lip; ; superior surface of tongue; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; metal ion binding; damaged DNA binding; protein binding; WW domain binding; double-stranded DNA binding; DNA binding; sequence-specific DNA binding; identical protein binding; chromatin binding; p53 binding; DNA-binding transcription factor activity; MDM2/MDM4 family protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein domain specific binding;
Cellular component	cytoplasm; neuron projection; nucleus; rough endoplasmic reticulum; transcription regulator complex; nucleoplasm; dendrite; mitochondrion; Golgi apparatus; cytosol; protein-containing complex;
Biological process	pattern specification process; skeletal system development; epithelial cell development; negative regulation of keratinocyte differentiation; epidermal cell division; anatomical structure formation involved in morphogenesis; prostate gland development; transcription by RNA polymerase II; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; ectoderm and mesoderm interaction; cellular response to DNA damage stimulus; female genitalia morphogenesis; odontogenesis of dentin-containing tooth; prostatic bud formation; positive regulation of cell cycle G1/S phase transition; positive regulation of mesenchymal cell proliferation; spermatogenesis; multicellular organism aging; smooth muscle tissue development; positive regulation of fibroblast apoptotic process; animal organ morphogenesis; hair follicle morphogenesis; positive regulation of Notch signaling pathway; apoptotic process; chromatin remodeling; regulation of transcription, DNA-templated; regulation of neuron apoptotic process; positive regulation of apoptotic signaling pathway; regulation of cysteine-type endopeptidase activity involved in apoptotic process; transcription, DNA-templated; embryonic limb morphogenesis; negative regulation of mesoderm development; epidermis development; post-anal tail morphogenesis; response to gamma radiation; protein homotetramerization; Notch signaling pathway; hair follicle development; neuron apoptotic process; polarized epithelial cell differentiation; proximal/distal pattern formation; cell differentiation; positive regulation of keratinocyte proliferation; skin morphogenesis; epithelial cell differentiation; urinary bladder development; cellular response to UV; establishment of planar polarity; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; protein tetramerization; keratinocyte proliferation; positive regulation of osteoblast differentiation; regulation of epidermal cell division; negative regulation of transcription, DNA-templated; negative regulation of cellular senescence; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; sympathetic nervous system development; establishment of skin barrier; morphogenesis of a polarized epithelium; keratinocyte differentiation; multicellular organism development; mitotic G1 DNA damage checkpoint signaling; cloacal septation; response to X-ray; positive regulation of transcription by RNA polymerase II; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of signal transduction by p53 class mediator; regulation of apoptotic process; ageing; negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of transcription, DNA-templated; positive regulation of somatic stem cell population maintenance; cell population proliferation; epidermal cell differentiation; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; skin epidermis development; cranial skeletal system development; developmental process;
	Sources:Amigo / QuickGO
Orthologs
	8626
	22061
	ENSG00000073282
	ENSMUSG00000022510
	Q9H3D4
	O88898
NM_001114978; NM_001114979; NM_001114980; NM_001114981; NM_001114982;
	NM_003722; NM_001329144; NM_001329145; NM_001329146; NM_001329148; NM_001329149; NM_001329150; NM_001329964
NM_001127259; NM_001127260; NM_001127261; NM_001127262; NM_001127263;
	NM_001127264; NM_001127265; NM_011641
NP_001108450; NP_001108451; NP_001108452; NP_001108453; NP_001108454;
	NP_001316073; NP_001316074; NP_001316075; NP_001316077; NP_001316078; NP_001316079; NP_001316893; NP_003713
NP_001120731; NP_001120732; NP_001120733; NP_001120734; NP_001120735;
	NP_001120736; NP_001120737; NP_035771
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor protein p63, typically referred to as p63, also known as transformation-related protein 63, is a protein that in humans is encoded by the TP63 (also known as the p63) gene.

The TP63 gene was discovered 20 years after the discovery of the p53 tumor suppressor gene and along with p73 constitutes the p53 gene family based on their structural similarity. Despite being discovered significantly later than p53, phylogenetic analysis of p53, p63 and p73, suggest that p63 was the original member of the family from which p53 and p73 evolved.