TPCN1

TPCN1
Identifiers
Aliases	TPCN1, TPC1, two pore segment channel 1
External IDs	OMIM: 609666; MGI: 2182472; HomoloGene: 9905; GeneCards: TPCN1; OMA:TPCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	113,298,585 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	120,726,738 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastric mucosa; ; apex of heart; ; right adrenal gland; ; right adrenal cortex; ; body of pancreas; ; left adrenal cortex; ; left ovary;
	Top expressed in
	lacrimal gland; ; saccule; ; otic vesicle; ; yolk sac; ; aortic valve; ; ankle; ; intestinal villus; ; molar; ; ascending aorta; ; submandibular gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; identical protein binding; NAADP-sensitive calcium-release channel activity; voltage-gated calcium channel activity; calcium activated cation channel activity;
Cellular component	integral component of membrane; endosome; membrane; plasma membrane; lysosomal membrane; lysosome; endosome membrane; CatSper complex;
Biological process	membrane depolarization during action potential; positive regulation of autophagy; regulation of ion transmembrane transport; ion transport; ion transmembrane transport; calcium ion transmembrane transport; calcium ion transport; transmembrane transport; release of sequestered calcium ion into cytosol; flagellated sperm motility;
	Sources:Amigo / QuickGO
Orthologs
	53373
	252972
	ENSG00000186815
	ENSMUSG00000032741
	Q9ULQ1
	Q9EQJ0
	NM_001143819; NM_001301214; NM_017901; NM_001351346; NM_001351347
	NM_145853
	NP_001137291; NP_001288143; NP_060371; NP_001338275; NP_001338276
	NP_665852
	Wikidata
View/Edit Human	View/Edit Mouse

Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene. The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing six transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).