TPCN2

TPCN2
Identifiers
Aliases	TPCN2, SHEP10, TPC2, two pore segment channel 2
External IDs	OMIM: 612163; MGI: 2385297; HomoloGene: 16375; GeneCards: TPCN2; OMA:TPCN2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	69,136,316 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,837,748 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; mucosa of ileum; ; gastric mucosa; ; muscle layer of sigmoid colon; ; body of uterus; ; monocyte; ; right hemisphere of cerebellum; ; tibialis anterior muscle; ; left uterine tube; ; right lobe of liver;
	Top expressed in
	granulocyte; ; inner renal medulla; ; stroma of bone marrow; ; lip; ; ventricular zone; ; spermatid; ; yolk sac; ; embryo; ; blastocyst; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; voltage-gated ion channel activity; ion channel activity; protein binding; identical protein binding; protein kinase binding; NAADP-sensitive calcium-release channel activity; voltage-gated calcium channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; endosome membrane; lysosome; lysosomal membrane;
Biological process	release of sequestered calcium ion into cytosol; membrane depolarization during action potential; response to vitamin D; regulation of ion transmembrane transport; cellular calcium ion homeostasis; ion transport; ion transmembrane transport; regulation of autophagy; calcium ion transmembrane transport; lysosome organization; calcium-mediated signaling; calcium ion transport; transmembrane transport; smooth muscle contraction;
	Sources:Amigo / QuickGO
Orthologs
	219931
	233979
	ENSG00000162341
	ENSMUSG00000048677
	Q8NHX9
	Q8BWC0
	NM_139075
	NM_146206
	NP_620714
	NP_666318
	Wikidata
View/Edit Human	View/Edit Mouse

Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene. TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).