TPX2

TPX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OL5, 3E5A, 3HA6, 4C3P
Identifiers
Aliases	TPX2, C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100, microtubule nucleation factor, TPX2 microtubule nucleation factor
External IDs	OMIM: 605917; MGI: 1919369; HomoloGene: 8107; GeneCards: TPX2; OMA:TPX2 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	31,801,805 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,737,241 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; oocyte; ; gonad; ; secondary oocyte; ; bone marrow; ; testicle; ; trabecular bone; ; right testis; ; left testis;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; zygote; ; fetal liver hematopoietic progenitor cell; ; secondary oocyte; ; primitive streak; ; epiblast; ; endothelial cell of lymphatic vessel; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTP binding; importin-alpha family protein binding; ATP binding; protein binding; protein kinase binding;
Cellular component	cytoplasm; nucleus; spindle pole; microtubule; microtubule cytoskeleton; axon hillock; cytoskeleton; spindle; cytosol; nucleoplasm; mitotic spindle; microtubule organizing center; intercellular bridge;
Biological process	regulation of mitotic spindle organization; cell cycle; cell division; apoptotic process; mitotic spindle assembly; cell population proliferation; activation of protein kinase activity; regulation of signal transduction by p53 class mediator; mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	22974
	72119
	ENSG00000088325
	ENSMUSG00000027469
	Q9ULW0
	A2APB8
	NM_012112
	NM_001141975; NM_001141976; NM_001141977; NM_001141978; NM_028109
	NP_036244
	NP_001135447; NP_001135448; NP_001135449; NP_001135450; NP_082385
	Wikidata
View/Edit Human	View/Edit Mouse

Targeting protein for Xklp2 is a protein that in humans is encoded by the TPX2 gene. It is one of the many spindle assembly factors that play a key role in inducing microtubule assembly and growth during M phase.