TRA2B

TRA2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQC, 2KXN, 2RRA, 2RRB
Identifiers
Aliases	TRA2B, Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B, transformer 2 beta homolog (Drosophila), transformer 2 beta homolog
External IDs	OMIM: 602719; MGI: 106016; HomoloGene: 20965; GeneCards: TRA2B; OMA:TRA2B - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	185,938,103 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	22,084,755 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; parietal pleura; ; ventricular zone; ; embryo; ; visceral pleura; ; endothelial cell; ; ganglionic eminence; ; amniotic fluid; ; tibia; ; epithelium of nasopharynx;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; yolk sac; ; embryo; ; embryo; ; spermatocyte; ; neural layer of retina; ; morula; ; blastocyst;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; mRNA binding; protein binding; poly-purine tract binding; RNA binding; protein domain specific binding; pre-mRNA binding; identical protein binding;
Cellular component	nucleus; nuclear inner membrane; nucleoplasm; spliceosomal complex; ribonucleoprotein complex;
Biological process	RNA splicing, via transesterification reactions; RNA splicing; cerebral cortex regionalization; mRNA processing; negative regulation of mRNA splicing, via spliceosome; embryonic brain development; mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; regulation of alternative mRNA splicing, via spliceosome; regulation of RNA splicing; protein complex oligomerization; cellular response to glucose stimulus;
	Sources:Amigo / QuickGO
Orthologs
	6434
	20462
	ENSG00000136527
	ENSMUSG00000022858
	P62995
	P62996
	NM_001243879; NM_004593
	NM_009186; NM_001330554; NM_001330555
	NP_001230808; NP_004584
	NP_001317483; NP_001317484; NP_033212
	Wikidata
View/Edit Human	View/Edit Mouse

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

TRA2B contains a poison exon whose inclusion is autoregulated by TRA2B protein. Proper regulation of poison exon inclusion in TRA2B is important for T cell fate.