TRAF3IP2

TRAF3IP2
Identifiers
Aliases	TRAF3IP2, ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13, TRAF3 interacting protein 2
External IDs	OMIM: 607043; MGI: 2143599; HomoloGene: 15885; GeneCards: TRAF3IP2; OMA:TRAF3IP2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	111,606,906 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	39,531,303 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; oocyte; ; skin of leg; ; skin of abdomen; ; body of uterus; ; mucosa of transverse colon; ; epithelium of colon; ; islet of Langerhans; ; ectocervix; ; olfactory zone of nasal mucosa;
	Top expressed in
	lacrimal gland; ; parotid gland; ; lip; ; genital tubercle; ; neural layer of retina; ; seminal vesicula; ; Paneth cell; ; duodenum; ; uterus; ; large intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding;
Cellular component	intracellular anatomical structure; cellular component;
Biological process	positive regulation of I-kappaB kinase/NF-kappaB signaling; intracellular signal transduction; humoral immune response; B cell apoptotic process; positive regulation of defense response to virus by host;
	Sources:Amigo / QuickGO
Orthologs
	10758
	103213
	ENSG00000056972
	ENSMUSG00000019842
	O43734
	Q8N7N6
	NM_001164281; NM_001164282; NM_001164283; NM_147200; NM_147686
	NM_134000
	NP_001157753; NP_001157755; NP_671733; NP_679211
	NP_598761
	Wikidata
View/Edit Human	View/Edit Mouse

Adapter protein CIKS is a protein that in humans is encoded by the TRAF3IP2 gene.

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.