Death receptor 4

TNFRSF10A
Identifiers
Aliases	TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1, tumor necrosis factor receptor superfamily member 10a, TNF receptor superfamily member 10a
External IDs	OMIM: 603611; MGI: 1341090; HomoloGene: 129806; GeneCards: TNFRSF10A; OMA:TNFRSF10A - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	23,225,102 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,021,860 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; nipple; ; pancreatic ductal cell; ; tendon of biceps brachii; ; pylorus; ; lymph node; ; superficial temporal artery; ; epithelium of colon; ; mucosa of pharynx; ; nasal epithelium;
	Top expressed in
	urethra; ; female urethra; ; male urethra; ; genital tubercle; ; morula; ; endothelial cell of lymphatic vessel; ; tail of embryo; ; lens; ; embryo; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	TRAIL binding; transcription factor binding; protease binding; protein binding; tumor necrosis factor-activated receptor activity; death receptor activity; signaling receptor activity;
Cellular component	membrane; plasma membrane; integral component of plasma membrane; cell surface; intracellular anatomical structure; integral component of membrane;
Biological process	activation of NF-kappaB-inducing kinase activity; TRAIL-activated apoptotic signaling pathway; multicellular organism development; cell surface receptor signaling pathway; response to lipopolysaccharide; cellular response to mechanical stimulus; regulation of cell population proliferation; immune response; regulation of extrinsic apoptotic signaling pathway via death domain receptors; inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; extrinsic apoptotic signaling pathway via death domain receptors; signal transduction; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; extrinsic apoptotic signaling pathway; tumor necrosis factor-mediated signaling pathway; apoptotic process; leukocyte migration; regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8797
	21933
	ENSG00000104689
	ENSMUSG00000022074
	O00220
	Q9QZM4
	NM_003844
	NM_020275
	NP_003835
	NP_064671
	Wikidata
View/Edit Human	View/Edit Mouse

Death receptor 4 (DR4), also known as TRAIL receptor 1 (TRAILR1) and tumor necrosis factor receptor superfamily member 10A (TNFRSF10A), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.