TRAF interacting protein

TRAIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZTD
Identifiers
Aliases	TRAIP, RNF206, TRIP, SCKL9, TRAF interacting protein
External IDs	OMIM: 605958; MGI: 1096377; HomoloGene: 31343; GeneCards: TRAIP; OMA:TRAIP - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	49,856,574 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,849,469 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; ventricular zone; ; ganglionic eminence; ; mucosa of transverse colon; ; left testis; ; right testis; ; stromal cell of endometrium; ; rectum; ; nucleus accumbens;
	Top expressed in
	tail of embryo; ; gastrula; ; genital tubercle; ; fetal liver hematopoietic progenitor cell; ; morula; ; morula; ; otic placode; ; zygote; ; yolk sac; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein binding; metal ion binding; ubiquitin protein ligase activity; transferase activity; zinc ion binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleolus; nucleus;
Biological process	cell population proliferation; protein ubiquitination; negative regulation of interferon-beta production; signal transduction; negative regulation of tumor necrosis factor-mediated signaling pathway; apoptotic process; negative regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	10293
	22036
	ENSG00000183763
	ENSMUSG00000032586
	Q9BWF2
	Q8VIG6
	NM_005879
	NM_011634
	NP_005870
	NP_035764
	Wikidata
View/Edit Human	View/Edit Mouse

TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.