TRDMT1

TRDMT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G55
Identifiers
Aliases	TRDMT1, DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1, tRNA aspartic acid methyltransferase 1
External IDs	OMIM: 602478; MGI: 1274787; HomoloGene: 3249; GeneCards: TRDMT1; OMA:TRDMT1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	17,202,054 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	13,549,479 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; buccal mucosa cell; ; Achilles tendon; ; ganglionic eminence; ; right uterine tube; ; testicle; ; epithelium of colon; ; monocyte; ; sural nerve; ; gonad;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; atrioventricular valve; ; spermatocyte; ; granulocyte; ; secondary oocyte; ; zygote; ; primitive streak; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; tRNA methyltransferase activity; RNA binding; tRNA (cytosine-5-)-methyltransferase activity;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	response to amphetamine; methylation; tRNA methylation; tRNA modification; tRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	1787
	13434
	ENSG00000107614
	ENSMUSG00000026723
	O14717
	O55055
NM_004412; NM_176081; NM_176083; NM_176084; NM_176085;
	NM_176086; NM_001321006; NM_001321007; NM_001351219; NM_001351220; NM_001351221; NM_001351222; NM_001351223
	NM_010067
NP_001307935; NP_001307936; NP_004403; NP_001338148; NP_001338149;
	NP_001338150; NP_001338151; NP_001338152
	NP_034197
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the TRDMT1 gene.

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.

It has been shown that human DNMT2 does not methylate DNA but instead methylates cytosine 38 in the anticodon loop of aspartic acid transfer RNA (tRNA(Asp)).