TREML1

TREML1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FRG
Identifiers
Aliases	TREML1, GLTL1825, PRO3438, TLT-1, TLT1, dJ238O23.3, triggering receptor expressed on myeloid cells like 1
External IDs	OMIM: 609714; MGI: 1918576; HomoloGene: 52257; GeneCards: TREML1; OMA:TREML1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,154,347 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	48,674,204 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; spleen; ; appendix; ; C1 segment; ; bone marrow cells; ; lymph node; ; right lung; ; upper lobe of left lung;
	Top expressed in
	bone marrow; ; spleen; ; embryo; ; lobe of liver; ; white adipose tissue; ; morula; ; yolk sac; ; placenta; ; lung; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; membrane; cell surface; platelet alpha granule;
Biological process	innate immune response; calcium-mediated signaling; regulation of immune response; platelet activation;
	Sources:Amigo / QuickGO
Orthologs
	340205
	71326
	ENSG00000161911
	ENSMUSG00000023993
	Q86YW5
	Q8K558
	NM_178174; NM_001271807; NM_001271808
	NM_001289451; NM_001289457; NM_027763
	NP_001258736; NP_001258737; NP_835468
	NP_001276380; NP_001276386; NP_082039
	Wikidata
View/Edit Human	View/Edit Mouse

Trem-like transcript 1 protein is a protein that in humans is encoded by the TREML1 gene.

TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties.

TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003; Barrow et al., 2004).[supplied by OMIM]