TRIM21

TRIM21
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IWG
Identifiers
Aliases	TRIM21, RNF81, RO52, Ro/SSA, SSA, SSA1, tripartite motif containing 21, Tripartite motif-containing protein 21
External IDs	OMIM: 109092; MGI: 106657; HomoloGene: 2365; GeneCards: TRIM21; OMA:TRIM21 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	4,393,702 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	102,214,693 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; mucosa of transverse colon; ; spleen; ; rectum; ; epithelium of colon; ; apex of heart; ; Descending thoracic aorta; ; mucosa of ileum;
	Top expressed in
	Ileal epithelium; ; Paneth cell; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; thymus; ; blood; ; granulocyte; ; carotid body; ; spleen; ; Epithelium of choroid plexus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; protein binding; RNA binding; identical protein binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; cytosol; SCF ubiquitin ligase complex; P-body; intracellular anatomical structure; autophagosome; cytoplasmic vesicle; nucleus; nucleoplasm; ribonucleoprotein complex;
Biological process	negative regulation of protein deubiquitination; response to interferon-gamma; positive regulation of autophagy; interferon-gamma-mediated signaling pathway; protein trimerization; positive regulation of viral entry into host cell; positive regulation of DNA-binding transcription factor activity; protein monoubiquitination; regulation of type I interferon production; positive regulation of cell cycle; protein destabilization; protein ubiquitination; cell cycle; negative regulation of NF-kappaB transcription factor activity; protein autoubiquitination; innate immune response; protein polyubiquitination; negative regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	6737
	20821
	ENSG00000132109
	ENSMUSG00000030966
	P19474
	Q62191
	NM_003141
	NM_001082552; NM_009277
	NP_003132
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 21, also known as E3 ubiquitin-protein ligase TRIM21, is a protein that in humans is encoded by the TRIM21 gene. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. It is expressed in most human tissues.