TRIM25

TRIM25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CFG, 4LTB, 5FER
Identifiers
Aliases	TRIM25, EFP, RNF147, Z147, ZNF147, tripartite motif containing 25
External IDs	OMIM: 600453; MGI: 102749; HomoloGene: 48325; GeneCards: TRIM25; OMA:TRIM25 - orthologs
EC number	2.3.2.27
Gene location (Human)
Chr.	Chromosome 17 (human)
End	56,914,080 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	88,911,119 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; blood; ; pancreatic epithelial cell; ; lower lobe of lung; ; jejunal mucosa; ; monocyte; ; appendix; ; thymus; ; skin of hip; ; spleen;
	Top expressed in
	Paneth cell; ; medullary collecting duct; ; renal corpuscle; ; semi-lunar valve; ; conjunctival fornix; ; retinal pigment epithelium; ; ciliary body; ; endothelial cell of lymphatic vessel; ; ureter; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA-binding transcription factor activity; ubiquitin protein ligase activity; metal ion binding; ligase activity; protein binding; ubiquitin-protein transferase activity; RNA binding; cadherin binding; zinc ion binding;
Cellular component	nucleoplasm; cytoplasm; cytosol; nuclear body; intracellular anatomical structure;
Biological process	ERAD pathway; negative regulation of viral entry into host cell; immune system process; interferon-gamma-mediated signaling pathway; positive regulation of DNA-binding transcription factor activity; protein monoubiquitination; defense response to virus; positive regulation of NF-kappaB transcription factor activity; protein ubiquitination; positive regulation of I-kappaB kinase/NF-kappaB signaling; translesion synthesis; negative regulation of type I interferon production; innate immune response; viral process; response to estrogen; response to vitamin D; protein deubiquitination; ubiquitin-dependent ERAD pathway; cellular response to leukemia inhibitory factor; ubiquitin-dependent protein catabolic process; regulation of viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	7706
	217069
	ENSG00000121060
	ENSMUSG00000000275
	Q14258
	Q61510
	NM_005082
	NM_009546
	NP_005073
	NP_033572
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 25 is a protein that in humans is encoded by the TRIM25 gene.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family grouping more than 70 TRIMs. TRIM proteins primarily function as ubiquitin ligases that regulate the innate response to infection. TRIM25 localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.