TRIM27

TRIM27
Identifiers
Aliases	TRIM27, RFP, RNF76, tripartite motif containing 27
External IDs	OMIM: 602165; MGI: 97904; HomoloGene: 111010; GeneCards: TRIM27; OMA:TRIM27 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	28,923,988 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	21,378,894 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; body of pancreas; ; right lobe of liver; ; endometrium; ; canal of the cervix; ; blood; ; spleen; ; pituitary gland; ; anterior pituitary; ; granulocyte;
	Top expressed in
	internal carotid artery; ; Paneth cell; ; external carotid artery; ; condyle; ; fossa; ; primary oocyte; ; Rostral migratory stream; ; spermatid; ; primitive streak; ; lacrimal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; nucleic acid binding; transmembrane receptor protein tyrosine kinase activity; identical protein binding; transferase activity; ubiquitin protein ligase activity; SUMO transferase activity;
Cellular component	cytoplasm; endosome; PML body; nuclear membrane; membrane; integral component of plasma membrane; intracellular anatomical structure; nucleoplasm; retromer complex; early endosome; nucleus; fibrillar center; nucleolus; cytosol;
Biological process	regulation of transcription, DNA-templated; negative regulation of adaptive immune response; negative regulation of protein kinase activity; protein K63-linked ubiquitination; protein trimerization; positive regulation of DNA-binding transcription factor activity; transcription, DNA-templated; negative regulation of calcium ion import; negative regulation of gene expression, epigenetic; retrograde transport, endosome to Golgi; spermatogenesis; Arp2/3 complex-mediated actin nucleation; negative regulation of tumor necrosis factor production; cell population proliferation; peptidyl-tyrosine phosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of viral transcription; innate immune response; positive regulation of actin nucleation; protein sumoylation;
	Sources:Amigo / QuickGO
Orthologs
	5987
	19720
ENSG00000229006; ENSG00000233948; ENSG00000204713; ENSG00000215641; ENSG00000237071;
	ENSG00000237462; ENSG00000234495
	ENSMUSG00000021326
	P14373
	Q62158
	NM_030950; NM_006510
	NM_009054
	NP_006501
	NP_033080
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.