TRIM28

TRIM28
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FP0, 2RO1, 2YVR
Identifiers
Aliases	TRIM28, KAP1, PPP1R157, RNF96, TF1B, TIF1B, tripartite motif containing 28, TIF1beta
External IDs	OMIM: 601742; MGI: 109274; HomoloGene: 21175; GeneCards: TRIM28; OMA:TRIM28 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	58,550,722 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	12,764,962 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; ventricular zone; ; ganglionic eminence; ; stromal cell of endometrium; ; left ovary; ; right ovary; ; body of uterus; ; gonad; ; right uterine tube;
	Top expressed in
	epiblast; ; spermatocyte; ; spermatid; ; ventricular zone; ; internal carotid artery; ; somite; ; morula; ; blastocyst; ; genital tubercle; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; Krueppel-associated box domain binding; chromo shadow domain binding; transcription corepressor activity; promoter-specific chromatin binding; transcription coactivator activity; metal ion binding; ubiquitin-protein transferase activity; protein binding; ubiquitin protein ligase binding; DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; chromatin binding; zinc ion binding; RNA binding; transferase activity; SUMO transferase activity;
Cellular component	intracellular anatomical structure; chromatin; RNA polymerase II transcription regulator complex; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; positive regulation of DNA methylation-dependent heterochromatin assembly; convergent extension involved in axis elongation; embryonic placenta morphogenesis; positive regulation of DNA repair; in utero embryonic development; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of DNA demethylation; protein phosphorylation; protein complex oligomerization; protein autophosphorylation; DNA methylation involved in embryo development; Ras protein signal transduction; transcription initiation from RNA polymerase II promoter; DNA repair; embryo implantation; positive regulation of transcription by RNA polymerase II; regulation of genetic imprinting; protein sumoylation; epithelial to mesenchymal transition; protein ubiquitination; negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; positive regulation of DNA binding; innate immune response; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; chromatin organization; viral process; positive regulation of protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	10155
	21849
	ENSG00000130726
	ENSMUSG00000005566
	Q13263
	Q62318
	NM_005762
	NM_011588
	NP_005753
	NP_035718
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KRAB-associated protein-1 (KAP1), is a protein that in humans is encoded by the TRIM28 gene.