TRIM5alpha

TRIM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ECV, 2YRG
Identifiers
Aliases	TRIM5, RNF88, TRIM5alpha, tripartite motif containing 5
External IDs	OMIM: 608487; MGI: 4821183; HomoloGene: 75345; GeneCards: TRIM5; OMA:TRIM5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	5,938,619 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	104,002,569 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; germinal epithelium; ; palpebral conjunctiva; ; stromal cell of endometrium; ; body of pancreas; ; seminal vesicula; ; monocyte; ; Descending thoracic aorta; ; visceral pleura; ; blood;
	Top expressed in
	granulocyte; ; thymus; ; female urethra; ; duodenum; ; bone marrow; ; aortic valve; ; spleen; ; ascending aorta; ; esophagus; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein homodimerization activity; pattern recognition receptor activity; zinc ion binding; metal ion binding; protein binding; identical protein binding; protein kinase binding; transferase activity; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; cytosol; omegasome; intracellular anatomical structure; nucleus; P-body;
Biological process	regulation of lipopolysaccharide-mediated signaling pathway; interferon-gamma-mediated signaling pathway; protein K63-linked ubiquitination; immune system process; protein trimerization; positive regulation of DNA-binding transcription factor activity; regulation of protein localization; autophagy; positive regulation of NF-kappaB transcription factor activity; defense response to virus; protein ubiquitination; activation of innate immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response; viral process; positive regulation of MAPK cascade; pattern recognition receptor signaling pathway; negative regulation of viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	85363
	319236
	ENSG00000132256
	ENSMUSG00000057143
	Q9C035
	D3Z3L3
	NM_033034; NM_033092; NM_033093
	NM_001146007; NM_175677
	NP_149023; NP_149083; NP_149084
	NP_001139479; NP_783608
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 5 also known as RING finger protein 88 is a protein that in humans is encoded by the TRIM5 gene. The alpha isoform of this protein, TRIM5α, is a retrovirus restriction factor, which mediates a species-specific early block to retrovirus infection.

TRIM5α is composed of 493 amino acids which is found in the cells of most primates. TRIM5α is an intrinsic immune factor important in the innate immune defense against retroviruses, along with the APOBEC family of proteins, tetherin and TRIM22.