TRPC6

TRPC6
Identifiers
Aliases	TRPC6, FSGS2, TRP6, transient receptor potential cation channel subfamily C member 6
External IDs	OMIM: 603652; MGI: 109523; HomoloGene: 37944; GeneCards: TRPC6; OMA:TRPC6 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	101,872,562 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	8,680,742 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; right uterine tube; ; testicle; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; Achilles tendon; ; stromal cell of endometrium; ; visceral pleura; ; subcutaneous adipose tissue;
	Top expressed in
	lumbar spinal ganglion; ; right lobe of liver; ; dentate gyrus of hippocampal formation granule cell; ; lens; ; cumulus cell; ; substantia nigra; ; embryo; ; hippocampus proper; ; left lung lobe; ; body of femur;
	More reference expression data
	n/a
Gene ontology
Molecular function	actinin binding; store-operated calcium channel activity; clathrin binding; inositol 1,4,5 trisphosphate binding; ion channel activity; protein binding; actin binding; calcium channel activity; cation channel activity; protein homodimerization activity; ATPase binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; slit diaphragm; cation channel complex;
Biological process	regulation of cytosolic calcium ion concentration; positive regulation of cytosolic calcium ion concentration; ageing; cation transport; ion transport; single fertilization; platelet activation; positive regulation of ion transmembrane transporter activity; negative regulation of dendrite morphogenesis; positive regulation of peptidyl-threonine phosphorylation; calcium ion transmembrane transport; positive regulation of neuron differentiation; neuron differentiation; manganese ion transport; cellular response to hypoxia; calcium ion transport; cellular response to hydrogen peroxide; positive regulation of calcium ion transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	7225
	22068
	ENSG00000137672
	ENSMUSG00000031997
	Q9Y210
	Q61143
	NM_004621
	NM_001282086; NM_001282087; NM_013838
	NP_004612
	NP_001269015; NP_001269016; NP_038866
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel, subfamily C, member 6 or Transient receptor potential canonical 6, also known as TRPC6, is a protein encoded in the human by the TRPC6 gene. TRPC6 is a transient receptor potential channel of the classical TRPC subfamily.

TRPC6 channels are nonselective cation channels that respond directly to diacylglycerol (DAG), a product of phospholipase C activity. This activation leads to cellular depolarization and calcium influx.

Unlike the closely related TRPC3 channels, TRPC6 channels possess the distinctive ability to transport heavy metal ions. TRPC6 channels facilitate the transport of zinc ions, promoting their accumulation inside cells. In addition, despite their non-selectiveness, TRPC6 exhibits a strong preference for calcium ions, with a permeability ratio of calcium to sodium (P_Ca/P_Na) of roughly six. This selectivity is significantly higher compared to TRPC3, which displays a weaker preference for calcium with a (P_Ca/P_Na) ratio of only 1.1.