TRPM8

TRPM8
Identifiers
Aliases	TRPM8, LTRPC6, TRPP8, transient receptor potential cation channel subfamily M member 8, trp-p8, LTrpC-6
External IDs	OMIM: 606678; MGI: 2181435; HomoloGene: 23433; GeneCards: TRPM8; OMA:TRPM8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	234,019,522 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,317,015 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; prostate; ; testicle; ; pancreatic ductal cell; ; trigeminal ganglion; ; amniotic fluid; ; islet of Langerhans; ; gonad; ; endometrium; ; left testis;
	Top expressed in
	seminiferous tubule; ; spinal ganglia; ; spermatid; ; cerebellar cortex; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; ion channel activity; protein binding; calcium channel activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; membrane raft; external side of plasma membrane; plasma membrane;
Biological process	response to stimulus; sensory perception of temperature stimulus; cellular calcium ion homeostasis; cation transport; ion transport; protein homotrimerization; response to cold; detection of temperature stimulus; protein homotetramerization; thermoception; calcium ion transport; response to temperature stimulus; transmembrane transport; calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	79054
	171382
	ENSG00000144481
	ENSMUSG00000036251
	Q7Z2W7
	Q8R4D5
	NM_024080
	NM_134252
	NP_076985
	NP_599013
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation in humans. In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor).