TSEN15

TSEN15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GW6
Identifiers
Aliases	TSEN15, C1orf19, sen15, tRNA splicing endonuclease subunit 15, PCH2F
External IDs	OMIM: 608756; MGI: 1913887; HomoloGene: 12002; GeneCards: TSEN15; OMA:TSEN15 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	184,123,978 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	152,262,439 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; C1 segment; ; biceps brachii; ; vastus lateralis muscle; ; Skeletal muscle tissue of biceps brachii; ; corpus epididymis; ; Brodmann area 46; ; deltoid muscle; ; ventricular zone;
	Top expressed in
	yolk sac; ; epiblast; ; embryo; ; ventricular zone; ; embryo; ; quadriceps femoris muscle; ; olfactory bulb; ; placenta; ; heart; ; skeletal muscle tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA-intron endonuclease activity; nucleic acid binding; nuclease activity;
Cellular component	nucleolus; nucleus; nucleoplasm;
Biological process	mRNA processing; RNA phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA processing; tRNA splicing, via endonucleolytic cleavage and ligation; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	116461
	66637
	ENSG00000198860
	ENSMUSG00000014980
	Q8WW01
	Q8R3W5
	NM_001127394; NM_001300764; NM_001300766; NM_052965; NM_001363643
	NM_025677
	NP_001120866; NP_001287693; NP_001287695; NP_443197; NP_001350572
	NP_079953
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]