TSEN2

TSEN2
Identifiers
Aliases	TSEN2, PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDs	OMIM: 608753; MGI: 2141599; HomoloGene: 41622; GeneCards: TSEN2; OMA:TSEN2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	12,541,549 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	115,555,589 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; mucosa of transverse colon; ; gonad; ; ventricular zone; ; testicle; ; gastrocnemius muscle; ; body of pancreas; ; cerebellar hemisphere; ; right uterine tube; ; muscle of thigh;
	Top expressed in
	Rostral migratory stream; ; yolk sac; ; epiblast; ; primitive streak; ; interventricular septum; ; hand; ; superior cervical ganglion; ; otolith organ; ; embryo; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tRNA-intron endonuclease activity; protein binding; lyase activity; nucleic acid binding; nuclease activity;
Cellular component	centrosome; nucleolus; nucleus; tRNA-intron endonuclease complex; nucleoplasm; cytosol;
Biological process	mRNA processing; tRNA-type intron splice site recognition and cleavage; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA splicing, via endonucleolytic cleavage and ligation; RNA phosphodiester bond hydrolysis; tRNA processing; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	80746
	381802
	ENSG00000154743
	ENSMUSG00000042389
	Q8NCE0
	Q6P7W5
NM_001145392; NM_001145393; NM_001145394; NM_001145395; NM_025265;
	NM_001321277; NM_001321278; NM_001321279
	NM_199033
NP_001138864; NP_001138865; NP_001138866; NP_001308206; NP_001308207;
	NP_001308208; NP_079541
	NP_950198
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]