TSPAN2

TSPAN2
Identifiers
Aliases	TSPAN2, NET3, TSN2, TSPAN-2, tetraspanin 2
External IDs	OMIM: 613133; MGI: 1917997; HomoloGene: 21169; GeneCards: TSPAN2; OMA:TSPAN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	115,089,503 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	102,708,829 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; muscle layer of sigmoid colon; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; tail of epididymis; ; Descending thoracic aorta; ; ascending aorta; ; islet of Langerhans; ; gastric mucosa;
	Top expressed in
	ventral tegmental area; ; lateral geniculate nucleus; ; globus pallidus; ; deep cerebellar nuclei; ; left lung lobe; ; lateral hypothalamus; ; right lung; ; medial geniculate nucleus; ; right lung lobe; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; myelin sheath; plasma membrane; integral component of plasma membrane; membrane;
Biological process	astrocyte development; myelination; cell surface receptor signaling pathway; axon development; brain development; oligodendrocyte differentiation; inflammatory response; microglia development;
	Sources:Amigo / QuickGO
Orthologs
	10100
	70747
	ENSG00000134198
	ENSMUSG00000027858
	O60636
	Q922J6
	NM_001308315; NM_001308316; NM_005725
	NM_001243132; NM_027533
	NP_001295244; NP_001295245; NP_005716
	NP_001230061; NP_081809
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.