TST (gene)

TST
Identifiers
Aliases	TST, RDS, thiosulfate sulfurtransferase
External IDs	OMIM: 180370; MGI: 98852; HomoloGene: 37759; GeneCards: TST; OMA:TST - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,020,183 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,290,107 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right lobe of liver; ; mucosa of sigmoid colon; ; mucosa of ileum; ; right adrenal cortex; ; jejunal mucosa; ; duodenum; ; left adrenal gland; ; left adrenal cortex; ; kidney tubule;
	Top expressed in
	olfactory epithelium; ; left lobe of liver; ; pyloric antrum; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; esophagus; ; adrenal gland; ; left colon; ; optic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; 5S rRNA binding; thiosulfate sulfurtransferase activity; RNA binding;
Cellular component	mitochondrial inner membrane; extracellular exosome; mitochondrion; mitochondrial matrix; extracellular space;
Biological process	rRNA transport; rRNA import into mitochondrion; epithelial cell differentiation; cyanate catabolic process; sulfur amino acid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	7263
	22117
	ENSG00000128311
	ENSMUSG00000044986
	Q16762
	P52196
	NM_003312; NM_001270483
	NM_009437
	NP_001257412; NP_003303
	NP_033463
	Wikidata
View/Edit Human	View/Edit Mouse

Thiosulfate sulfurtransferase is an enzyme that in humans is encoded by the TST gene.

The product of this gene is a mitochondrial matrix enzyme that is encoded by the nucleus. It may play roles in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes.

The gene product contains two highly conservative domains (rhodanese homology domains), suggesting these domains have a common evolutionary origin.