TTK (gene)

TTK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 3WYX, 3WYY, 3WZJ, 3WZK, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4G, 4C4H, 4C4I, 4C4J, 4CV8, 4CV9, 4CVA, 4D2S, 4H7X, 4H7Y, 4JS8, 4JT3, 4O6L, 5AP0, 5AP1, 5AP2, 5AP3, 5AP4, 5AP5, 5AP6, 5AP7, 5EI2, 5EHY, 5EH0, 5EI6, 4ZEG, 5EI8
Identifiers
Aliases	TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase
External IDs	OMIM: 604092; MGI: 1194921; HomoloGene: 2489; GeneCards: TTK; OMA:TTK - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	80,042,527 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	83,754,442 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; gonad; ; testicle; ; ganglionic eminence; ; sperm; ; trabecular bone; ; right testis; ; left testis; ; bone marrow;
	Top expressed in
	zygote; ; primary oocyte; ; genital tubercle; ; tail of embryo; ; maxillary prominence; ; secondary oocyte; ; mandibular prominence; ; epiblast; ; spermatocyte; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; transferase activity; protein serine/threonine/tyrosine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; nucleotide binding; protein kinase activity; protein binding; ATP binding; protein homodimerization activity; kinetochore binding;
Cellular component	spindle; membrane; cytoplasm; kinetochore; nucleus;
Biological process	chromosome separation; mitotic spindle organization; positive regulation of pathway-restricted SMAD protein phosphorylation; spindle organization; mitotic spindle assembly checkpoint signaling; positive regulation of cell population proliferation; protein phosphorylation; phosphorylation; mitotic cell cycle checkpoint signaling; peptidyl-tyrosine phosphorylation; female meiosis chromosome segregation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; meiotic spindle assembly checkpoint signaling; protein localization to kinetochore; protein localization to chromosome; protein autophosphorylation; protein localization to meiotic spindle midzone; chromosome segregation;
	Sources:Amigo / QuickGO
Orthologs
	7272
	22137
	ENSG00000112742
	ENSMUSG00000038379
	P33981
	P35761
	NM_001166691; NM_003318
	NM_001110265; NM_001284272; NM_009445
	NP_001160163; NP_003309
	NP_001103735; NP_001271201; NP_033471
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene.