Tubulin beta-4A chain

TUBB4A
Identifiers
Aliases	TUBB4A, DYT4, TUBB4, TUBB5, beta-5, tubulin beta 4A class IVa
External IDs	OMIM: 602662; MGI: 107848; HomoloGene: 55952; GeneCards: TUBB4A; OMA:TUBB4A - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,502,848 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,394,782 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; Brodmann area 10; ; C1 segment; ; right frontal lobe; ; paraflocculus of cerebellum; ; middle frontal gyrus; ; anterior cingulate cortex; ; Amygdala; ; caudate nucleus; ; internal globus pallidus;
	Top expressed in
	primary visual cortex; ; CA3 field; ; perirhinal cortex; ; superior frontal gyrus; ; cerebellar cortex; ; entorhinal cortex; ; dentate gyrus of hippocampal formation granule cell; ; central gray substance of midbrain; ; neural layer of retina; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; structural constituent of cytoskeleton; protein binding; GTPase activity; calcium ion binding;
Cellular component	cytoplasm; cytosol; cell projection; myelin sheath; internode region of axon; cilium; soma; microtubule; extracellular exosome; cytoskeleton; nucleus; microtubule cytoskeleton; axoneme;
Biological process	G2/M transition of mitotic cell cycle; microtubule-based process; cytoskeleton organization; ciliary basal body-plasma membrane docking; negative regulation of microtubule polymerization; regulation of G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	10382
	22153
	ENSG00000104833
	ENSMUSG00000062591
	P04350
	Q9D6F9
NM_006087; NM_001289123; NM_001289127; NM_001289129; NM_001289130;
	NM_001289131
	NM_009451
NP_001276052; NP_001276056; NP_001276058; NP_001276059; NP_001276060;
	NP_006078
	NP_033477
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin beta-4A chain is a protein that in humans is encoded by the TUBB4A gene. Two tubulin beta-4 chain proteins are encoded in the human genome by the genes TUBB4A (this entry) and TUBB4B. Tubulin is the major constituent of microtubules, a key components of the cytoskeleton. It binds two molecules of GTP, one at an exchangeable site on the beta-chain and one at a non-exchangeable site on the alpha-chain. TUBB4A is preferentially and highly expressed in the central nervous system.