TWEETIO (psychedelics)

TWEETIO is a family of phenethylamine psychedelic drugs. They are analogues of the 2C drugs (4-substituted 2,5-dimethoxyphenethylamines) in which one or both of the methoxy groups at positions 2 and 5 of the phenyl ring have been lengthened to ethoxy groups. Examples include 2CD-2-ETO (a TWEETIO of 2C-D), 2CE-5-ETO (a TWEETIO of 2C-E), and 2CT2-5-ETO (a TWEETIO of 2C-T-2).

The TWEETIO drugs are said to have been named in a humorous way by pronouncing the simplest structural form of "2-EtO-X". Limited human data are available on the TWEETIO compounds. In any case, some generalizations have been made, including that the 2-ETO compounds tend to have a shorter duration and decreased potency, the 5-ETO drugs tend to have enhanced potency and remarkably increased durations, and the 2,5-Di-ETO drugs tend to be inactive.

The TWEETIO compounds were not the work of psychedelic chemist Alexander Shulgin, but were communicated to and reported by Shulgin in the scientific literature in the 1990s and 2000s. It was said by Shulgin in 2003 that the propoxy analogues had not yet been synthesized. In 2023, a propoxy derivative, ASR-2001 (2CB-5PrO), was first reported.