TWF2

TWF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VAC, 2W0I
Identifiers
Aliases	TWF2, A6RP, A6r, PTK9L, MSTP011, twinfilin actin binding protein 2
External IDs	OMIM: 607433; MGI: 1346078; HomoloGene: 5272; GeneCards: TWF2; OMA:TWF2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,246,788 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,092,588 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; granulocyte; ; gastrocnemius muscle; ; monocyte; ; glutes; ; left ventricle; ; triceps brachii muscle; ; blood; ; mucosa of transverse colon;
	Top expressed in
	intercostal muscle; ; granulocyte; ; soleus muscle; ; vestibular sensory epithelium; ; interventricular septum; ; thoracic diaphragm; ; medial head of gastrocnemius muscle; ; masseter muscle; ; muscle of thigh; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin monomer binding; protein binding; actin binding; phosphatidylinositol-4,5-bisphosphate binding; ATP binding; protein kinase C binding; RNA binding; cadherin binding; actin filament binding;
Cellular component	cell projection; filopodium; growth cone; intracellular anatomical structure; stereocilium; perinuclear region of cytoplasm; extracellular exosome; cytoskeleton; lamellipodium; cytoplasm; myofibril; actin filament;
Biological process	cellular response to retinoic acid; regulation of actin cytoskeleton organization; negative regulation of actin filament polymerization; cellular response to growth factor stimulus; cell projection organization; positive regulation of neuron projection development; positive regulation of axon extension; positive regulation of lamellipodium assembly; regulation of microvillus length; sequestering of actin monomers; barbed-end actin filament capping; regulation of lamellipodium assembly; actin filament depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	11344
	23999
	ENSG00000247596
	ENSMUSG00000023277
	Q6IBS0
	Q9Z0P5
	NM_007284
	NM_011876
	NP_009215
	NP_036006
	Wikidata
View/Edit Human	View/Edit Mouse

Twinfilin-2 is a protein that in humans is encoded by the TWF2 gene.

The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.