Twist-related protein 2

TWIST2
Identifiers
Aliases	TWIST2, DERMO1, FFDD3, SETLSS, bHLHa39, AMS, BBRSAY, twist family bHLH transcription factor 2
External IDs	OMIM: 607556; MGI: 104685; HomoloGene: 40594; GeneCards: TWIST2; OMA:TWIST2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	238,910,534 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,775,750 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; canal of the cervix; ; ectocervix; ; subcutaneous adipose tissue; ; vagina; ; lactiferous gland; ; left uterine tube; ; left ovary; ; right ovary; ; body of uterus;
	Top expressed in
	dermis; ; maxillary prominence; ; mandibular prominence; ; umbilical cord; ; efferent ductule; ; vas deferens; ; condyle; ; lamina propria of urethra; ; fossa; ; skin of abdomen;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; protein dimerization activity;
Cellular component	cytoplasm; nucleus; nucleolus;
Biological process	multicellular organism development; cell differentiation; negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of osteoblast differentiation; transcription, DNA-templated; positive regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	117581
	13345
	ENSG00000233608; ENSG00000288335
	ENSMUSG00000007805
	Q8WVJ9
	Q9D030
	NM_001271893; NM_057179
	NM_007855
	NP_001258822; NP_476527
	NP_031881
	Wikidata
View/Edit Human	View/Edit Mouse

Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene. The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor and shares similarity with another bHLH transcription factor, TWIST1. bHLH transcription factors have been implicated in cell lineage determination and differentiation. It is thought that during osteoblast development, this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype.