TWSG1

TWSG1
Identifiers
Aliases	TWSG1, TSG, twisted gastrulation BMP signaling modulator 1
External IDs	OMIM: 605049; MGI: 2137520; HomoloGene: 10774; GeneCards: TWSG1; OMA:TWSG1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	9,402,420 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	66,258,221 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; cartilage tissue; ; germinal epithelium; ; caput epididymis; ; corpus epididymis; ; tibia; ; tail of epididymis; ; visceral pleura; ; parietal pleura; ; Descending thoracic aorta;
	Top expressed in
	cumulus cell; ; tail of embryo; ; ascending aorta; ; aortic valve; ; medullary collecting duct; ; genital tubercle; ; corneal stroma; ; efferent ductule; ; right ventricle; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transforming growth factor beta binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of BMP signaling pathway; multicellular organism development; mesoderm formation; cell differentiation; forebrain development; camera-type eye development; salivary gland morphogenesis; BMP signaling pathway; ossification; negative regulation of osteoblast differentiation; tissue development; positive regulation of BMP signaling pathway; negative regulation of cytokine production; transforming growth factor beta receptor signaling pathway; positive regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of CD4-positive, alpha-beta T cell activation; negative regulation of CD4-positive, alpha-beta T cell proliferation; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	57045
	65960
	ENSG00000128791
	ENSMUSG00000024098
	Q9GZX9
	Q9EP52
	NM_020648
	NM_023053
	NP_065699
	NP_075540
	Wikidata
View/Edit Human	View/Edit Mouse

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene. The protein is a binding protein for bone morphogenetic proteins, similar to Chordin. The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.