Alpha-taxilin

TXLNA
Identifiers
Aliases	TXLNA, IL14, TXLN, IL-14, taxilin alpha
External IDs	OMIM: 608676; MGI: 105968; HomoloGene: 14062; GeneCards: TXLNA; OMA:TXLNA - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	32,198,285 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,534,858 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; tendon of biceps brachii; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; body of uterus; ; left adrenal cortex; ; right coronary artery; ; left uterine tube; ; anterior pituitary;
	Top expressed in
	hand; ; ventricular zone; ; mandibular prominence; ; lip; ; maxillary prominence; ; foot; ; genital tubercle; ; tail of embryo; ; epiblast; ; otolith organ;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; syntaxin binding; protein binding; high molecular weight B cell growth factor receptor binding;
Cellular component	cytoplasm; membrane; extracellular region; cytosol;
Biological process	B cell activation; cell population proliferation; exocytosis; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	200081
	109658
	ENSG00000084652
	ENSMUSG00000053841
	P40222
	Q6PAM1
	NM_175852; NM_001376857; NM_001376858; NM_001376859
	NM_001005506; NM_001199695
	NP_787048; NP_001363786; NP_001363787; NP_001363788
	NP_001005506; NP_001186624
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells. This molecule was also recently designated taxilin. IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.