TYMP (gene)

TYMP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UOU, 2J0F, 2WK5, 2WK6
Identifiers
Aliases	TYMP, thymidine phosphorylase, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
External IDs	OMIM: 131222; MGI: 1920212; HomoloGene: 1474; GeneCards: TYMP; OMA:TYMP - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,530,032 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,261,242 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; granulocyte; ; monocyte; ; right lung; ; upper lobe of left lung; ; olfactory zone of nasal mucosa; ; spleen; ; apex of heart; ; blood; ; right lobe of liver;
	Top expressed in
	liver; ; jejunum; ; colon; ; duodenum; ; spermatocyte; ; vagina; ; spermatid; ; testicle; ; proximal tubule; ; lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; pyrimidine-nucleoside phosphorylase activity; growth factor activity; pentosyltransferase activity; 1,4-alpha-oligoglucan phosphorylase activity; thymidine phosphorylase activity; protein homodimerization activity;
Cellular component	cytosol;
Biological process	cell differentiation; pyrimidine nucleoside salvage; pyrimidine nucleoside catabolic process; multicellular organism development; chemotaxis; angiogenesis; metabolism; pyrimidine nucleobase metabolic process; mitochondrial genome maintenance; pyrimidine nucleoside metabolic process; regulation of myelination; regulation of transmission of nerve impulse; regulation of gastric motility; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	1890
	72962
	ENSG00000025708
	ENSMUSG00000022615
	P19971
	Q99N42
	NM_001953; NM_001113755; NM_001113756; NM_001257988; NM_001257989
	NM_138302; NM_028405
	NP_001107227; NP_001107228; NP_001244917; NP_001244918; NP_001944
	NP_612175
	Wikidata
View/Edit Human	View/Edit Mouse

TYMP is a gene that encodes for the enzyme thymidine phosphorylase. The TYMP gene is also known as ECGF1 (endothelial cell growth factor 1, platelet-derived) and MNGIE due to its role in MNGIE syndrome.