TYRO3

TYRO3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RHF
Identifiers
Aliases	TYRO3, BYK, Dtk, RSE, Sky, Tif, Etk-2, Rek, TYRO3 protein tyrosine kinase
External IDs	OMIM: 600341; MGI: 104294; HomoloGene: 4585; GeneCards: TYRO3; OMA:TYRO3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	41,583,589 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,648,585 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; paraflocculus of cerebellum; ; middle frontal gyrus; ; right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; cerebellar vermis; ; C1 segment; ; cingulate gyrus;
	Top expressed in
	primary motor cortex; ; perirhinal cortex; ; olfactory epithelium; ; piriform cortex; ; olfactory tubercle; ; superior frontal gyrus; ; entorhinal cortex; ; cingulate gyrus; ; prefrontal cortex; ; primary visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; virus receptor activity; kinase activity; phosphatidylinositol 3-kinase binding; protein binding; protein heterodimerization activity; ATP binding; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity; Wnt-protein binding;
Cellular component	integral component of membrane; nuclear envelope; endoplasmic reticulum membrane; membrane; plasma membrane; integral component of plasma membrane; nucleus; cell surface; cytoplasm; receptor complex;
Biological process	vagina development; phosphorylation; negative regulation of lymphocyte activation; protein phosphorylation; viral entry into host cell; phosphatidylinositol 3-kinase signaling; protein autophosphorylation; viral process; signal transduction; natural killer cell differentiation; cell adhesion; negative regulation of innate immune response; spermatogenesis; platelet activation; forebrain cell migration; apoptotic cell clearance; substrate adhesion-dependent cell spreading; peptidyl-tyrosine phosphorylation; ovulation cycle; negative regulation of neuron apoptotic process; platelet aggregation; neuron cellular homeostasis; protein kinase B signaling; negative regulation of toll-like receptor signaling pathway; secretion by cell; negative regulation of inflammatory response; neuropeptide signaling pathway; negative regulation of signal transduction; Wnt signaling pathway; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7301
	22174
	ENSG00000092445
	ENSMUSG00000027298
	Q06418
	P55144
	NM_006293; NM_001330264
	NM_001290800; NM_019392
	NP_001317193; NP_006284
	NP_001277729; NP_062265
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.