Tenecteplase

Tenecteplase
Clinical data
Trade names	Tnkase
AHFS/Drugs.com	Monograph
MedlinePlus	a625007
License data	US DailyMed: Tenecteplase;
Routes of; administration	Intravenous
Drug class	Tissue plasminogen activator
ATC code	B01AD11 (WHO) ;
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Excretion	Liver
Identifiers
	IUPAC name Human tissue plasminogen activator;
CAS Number	191588-94-0 ;
DrugBank	DB00031 ;
ChemSpider	none;
UNII	WGD229O42W;
KEGG	D02837 ;
Chemical and physical data
Formula	C2561H3919N747O781S40
Molar mass	58951.37 g·mol−1
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Tenecteplase, sold under the brand name Tnkase among others, is an enzyme used as a thrombolytic drug.

Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain.

Tenecteplase was approved for medical use in the United States in June 2000.