Testicular dysgenesis syndrome

Testicular dysgenesis syndrome (TDS) is a hypothesized male reproduction-related condition characterized by the presence of symptoms and disorders such as hypospadias, cryptorchidism, poor semen quality, and testicular cancer. The concept was first introduced by N.E. Skakkebæk along with the department of Growth and Reproduction at Copenhagen University in a paper in Human Reproduction. The paper suggests the origin and underlying cause of TDS can be detected as early as in fetal life, where environmental and genomic factors could affect the development of the male reproductive system.