Thioredoxin reductase
| Thioredoxin reductase (low molecular weight) | |
|---|---|
| Identifiers | |
| Symbol | ? |
| InterPro | IPR005982 |
| PROSITE | PS00573 |
| SCOP2 | 1zof / SCOPe / SUPFAM |
| Thioredoxin/glutathione reductase selenoprotein (high molecular weight) | |
|---|---|
| Identifiers | |
| Symbol | ? |
| InterPro | IPR006338 |
| PROSITE | PS00573 |
| SCOP2 | 3dgh / SCOPe / SUPFAM |
Thioredoxin reductases (TR, TrxR) (EC 1.8.1.9) are enzymes that reduce thioredoxin (Trx). Two classes of thioredoxin reductase have been identified: one class in bacteria and some eukaryotes and one in animals. Bacterial TrxR also catalyzes the reduction of glutaredoxin like proteins known as NrdH. Both classes are flavoproteins which function as homodimers. Each monomer contains a FAD prosthetic group, a NADPH binding domain, and an active site containing a redox-active disulfide bond.