Thrombospondin
| Thrombospondin type 1 domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Thrombospondin-1 | |||||||||
| Identifiers | |||||||||
| Symbol | TSP_1 | ||||||||
| Pfam | PF00090 | ||||||||
| InterPro | IPR000884 | ||||||||
| SMART | SM00209 | ||||||||
| PROSITE | PS50092 | ||||||||
| SCOP2 | 1lsl / SCOPe / SUPFAM | ||||||||
| |||||||||
Thrombospondins (TSPs) are a family of secreted glycoproteins with antiangiogenic functions. Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the family, thrombospondin 1 (THBS1), was discovered in 1971 by Nancy L. Baenziger.