Thyroid hormone receptor
| Thyroid hormone receptor alpha | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | THRA | ||||||
| Alt. symbols | THRA1, THRA2, ERBA1 | ||||||
| NCBI gene | 7067 | ||||||
| HGNC | 11796 | ||||||
| OMIM | 190120 | ||||||
| RefSeq | NM_199334 | ||||||
| UniProt | P10827 | ||||||
| Other data | |||||||
| Locus | Chr. 17 q11.2-17q12 | ||||||
| |||||||
| Thyroid hormone receptor beta | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | THRB | ||||||
| Alt. symbols | ERBA2 | ||||||
| NCBI gene | 7068 | ||||||
| HGNC | 11799 | ||||||
| OMIM | 190160 | ||||||
| RefSeq | NM_000461 | ||||||
| UniProt | P10828 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p24.1-p22 | ||||||
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The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone. TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects that lead to second messenger activation, and corresponding cellular response.