Thyrotropin-releasing hormone

Thyrotropin-releasing hormone
Clinical data
ATC code	V04CJ02 (WHO) ;
Identifiers
CAS Number	24305-27-9;
PubChem CID	638678;
IUPHAR/BPS	2139;
DrugBank	DB09421;
ChemSpider	554166;
UNII	5Y5F15120W;
KEGG	C03958;
ChEBI	CHEBI:35940;
ChEMBL	ChEMBL1472 ;
CompTox Dashboard (EPA)	DTXSID0023533 ;
ECHA InfoCard	100.041.934
Chemical and physical data
Formula	C16H22N6O4
Molar mass	362.390 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)N;
	InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1; Key:XNSAINXGIQZQOO-SRVKXCTJSA-N;

thyrotropin-releasing hormone
thyrotropin-releasing hormone
	Structural formula of TRH
Identifiers
Symbol	TRH
NCBI gene	7200
HGNC	12298
OMIM	275120
RefSeq	NM_007117
UniProt	P20396
Other data
Locus	Chr. 3 q13.3-q21
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) as well as prolactin from the anterior pituitary.

TRH has been used clinically in diagnosis of hyperthyroidism, and for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans. Its pharmaceutical form is called protirelin (INN) (/proʊˈtaɪrɪlɪn/).

Clinical data
ATC code	V04CJ02 (WHO)
Identifiers
CAS Number	24305-27-9
PubChem CID	638678
IUPHAR/BPS	2139
DrugBank	DB09421
ChemSpider	554166
UNII	5Y5F15120W
KEGG	C03958
ChEBI	CHEBI:35940
ChEMBL	ChEMBL1472^Y
CompTox Dashboard (EPA)	DTXSID0023533
ECHA InfoCard	100.041.934
Chemical and physical data
Formula	C₁₆H₂₂N₆O₄
Molar mass	362.390 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)N
InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1 Key:XNSAINXGIQZQOO-SRVKXCTJSA-N