Tolterodine

Tolterodine
Clinical data
Trade names	Detrol, Detrusitol, others
Other names	PNU-200583E
AHFS/Drugs.com	Monograph
MedlinePlus	a699026
License data	US DailyMed: Tolterodine;
Pregnancy; category	AU: B3;
Routes of; administration	By mouth
ATC code	G04BD07 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	77%
Protein binding	Approximately 96.3%
Elimination half-life	1.9–3.7 hours
Identifiers
	IUPAC name (S)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-methylphenol;
CAS Number	124937-51-5 ; as salt: 124937-52-6;
PubChem CID	443879; as salt: 443878;
IUPHAR/BPS	360;
DrugBank	DB01036 ; as salt: DBSALT000467;
ChemSpider	391967 ; as salt: 391966;
UNII	WHE7A56U7K; as salt: 5T619TQR3R;
KEGG	D00646 ; as salt: D01148;
ChEBI	CHEBI:9622 ; as salt: CHEBI:32245;
ChEMBL	ChEMBL1382 ; as salt: ChEMBL1200871;
CompTox Dashboard (EPA)	DTXSID3023687 ;
ECHA InfoCard	100.232.068
Chemical and physical data
Formula	C22H31NO
Molar mass	325.496 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc(c(c1)[C@H](CCN(C(C)C)C(C)C)c2ccccc2)O;
	InChI InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1 ; Key:OOGJQPCLVADCPB-HXUWFJFHSA-N ;
	(verify)

Tolterodine, sold under the brand name Detrol among others, is a medication used to treat frequent urination, urinary incontinence, or urinary urgency. Effects are seen within an hour. It is taken by mouth.

Common side effects include headache, dry mouth, constipation, and dizziness. Serious side effects may include angioedema, urinary retention, and QT prolongation. Use in pregnancy and breastfeeding are of unclear safety. It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions.

Tolterodine was approved for medical use in 1998. It is available as a generic medication. In 2020, it was the 271st most commonly prescribed medication in the United States, with more than 1 million prescriptions.