TRPA1

TRPA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9P
Identifiers
Aliases	TRPA1, ANKTM1, FEPS, transient receptor potential cation channel subfamily A member 1, FEPS1
External IDs	OMIM: 604775; MGI: 3522699; HomoloGene: 7189; GeneCards: TRPA1; OMA:TRPA1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	72,075,584 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	14,989,086 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; mucosa of urinary bladder; ; mucosa of sigmoid colon; ; rectum; ; mucosa of ileum; ; epithelium of colon; ; jejunal mucosa; ; gonad; ; mucosa of transverse colon;
	Top expressed in
	lumbar spinal ganglion; ; secondary oocyte; ; primary oocyte; ; zygote; ; embryo; ; glossopharyngeal ganglion; ; embryo; ; epiblast; ; jejunum; ; colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	channel activity; calcium-release channel activity; ion channel activity; temperature-gated cation channel activity; calcium channel activity; identical protein binding;
Cellular component	stereocilium bundle; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane;
Biological process	response to organic cyclic compound; detection of chemical stimulus involved in sensory perception of pain; response to stimulus; ion transport; response to organic substance; cell surface receptor signaling pathway; response to pain; calcium ion transmembrane transport; response to cold; sensory perception of pain; protein homotetramerization; response to hydrogen peroxide; thermoception; calcium ion transport; detection of mechanical stimulus involved in sensory perception of pain; release of sequestered calcium ion into cytosol; transmembrane transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	8989
	277328
	ENSG00000104321
	ENSMUSG00000032769
	O75762
	Q8BLA8
	NM_007332
	NM_177781; NM_001348288
	NP_015628
	NP_808449; NP_001335217
	Wikidata
View/Edit Human	View/Edit Mouse

Transient receptor potential cation channel, subfamily A, member 1, also known as transient receptor potential ankyrin 1, TRPA1, or The Mustard and Wasabi Receptor, is a protein that in humans is encoded by the TRPA1 (and in mice and rats by the Trpa1) gene.

TRPA1 is an ion channel located on the plasma membrane of many human and animal cells. This ion channel is best known as a sensor for pain, cold and itch in humans and other mammals, as well as a sensor for environmental irritants giving rise to other protective responses (tears, airway resistance, and cough).