Transporter associated with antigen processing
| transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TAP1 | ||||||
| Alt. symbols | ABCB2 | ||||||
| NCBI gene | 6890 | ||||||
| HGNC | 43 | ||||||
| OMIM | 170260 | ||||||
| RefSeq | NM_000593 | ||||||
| UniProt | Q03518 | ||||||
| Other data | |||||||
| Locus | Chr. 6 p21.3 | ||||||
| |||||||
| transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TAP2 | ||||||
| Alt. symbols | ABCB3 | ||||||
| NCBI gene | 6891 | ||||||
| HGNC | 44 | ||||||
| OMIM | 170261 | ||||||
| RefSeq | NM_000544 | ||||||
| UniProt | Q03519 | ||||||
| Other data | |||||||
| Locus | Chr. 6 p21.3 | ||||||
| |||||||
Transporter associated with antigen processing (TAP) protein complex belongs to the ATP-binding-cassette transporter family. It delivers cytosolic peptides into the endoplasmic reticulum (ER), where they bind to nascent MHC class I molecules.
The TAP structure is formed of two proteins: TAP-1 and TAP-2, which have one hydrophobic region and one ATP-binding region each. They assemble into a heterodimer, which results in a four-domain transporter.