Transthyretin

TTR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BM7, 1BMZ, 1BZ8, 1BZD, 1BZE, 1DVQ, 1DVS, 1DVT, 1DVU, 1DVX, 1DVY, 1DVZ, 1E3F, 1E4H, 1E5A, 1ETA, 1ETB, 1F41, 1F86, 1FH2, 1FHN, 1G1O, 1GKO, 1ICT, 1III, 1IIK, 1IJN, 1QAB, 1QWH, 1RLB, 1SOK, 1SOQ, 1THA, 1THC, 1TLM, 1TSH, 1TT6, 1TTA, 1TTB, 1TTC, 1TTR, 1TYR, 1TZ8, 1U21, 1X7S, 1X7T, 1Y1D, 1Z7J, 1ZCR, 1ZD6, 2B14, 2B15, 2B16, 2B77, 2B9A, 2F7I, 2F8I, 2FBR, 2FLM, 2G3X, 2G3Z, 2G4E, 2G4G, 2G5U, 2G9K, 2GAB, 2H4E, 2M5N, 2NOY, 2PAB, 2QEL, 2QGB, 2QGC, 2QGD, 2QGE, 2ROX, 2ROY, 2TRH, 2TRY, 2WQA, 3A4D, 3A4E, 3A4F, 3B56, 3BSZ, 3BT0, 3CBR, 3CFM, 3CFN, 3CFQ, 3CFT, 3CN0, 3CN1, 3CN2, 3CN3, 3CN4, 3CXF, 3D7P, 3DGD, 3DID, 3DJR, 3DJS, 3DJT, 3DJZ, 3DK0, 3DK2, 3DO4, 3ESN, 3ESO, 3ESP, 3FC8, 3FCB, 3GLZ, 3GPS, 3GRB, 3GRG, 3GS0, 3GS4, 3GS7, 3HJ0, 3I9A, 3I9I, 3IPB, 3IPE, 3KGS, 3KGT, 3KGU, 3M1O, 3NEO, 3NES, 3NEX, 3NG5, 3OZK, 3OZL, 3SSG, 3TCT, 3TFB, 3U2I, 3U2J, 3W3B, 4ABQ, 4ABU, 4ABV, 4ABW, 4AC2, 4AC4, 4ACT, 4ANK, 4DER, 4DES, 4DET, 4DEU, 4DEW, 4FI6, 4FI7, 4FI8, 4HIQ, 4HIS, 4IIZ, 4IK6, 4IK7, 4IKI, 4IKJ, 4IKK, 4IKL, 5TTR, 3D2T, 3I9P, 3IMR, 3IMS, 3IMT, 3IMU, 3IMV, 3IMW, 3NEE, 3P3R, 3P3S, 3P3T, 3P3U, 4HJS, 4HJT, 4HJU, 4I85, 4I87, 4I89, 4KY2, 4L1S, 4L1T, 4MAS, 4MRB, 4MRC, 4N85, 4N86, 4N87, 4PM1, 4PME, 4PMF, 4PVL, 4PVM, 4PVN, 4PWE, 4PWF, 4PWG, 4PWH, 4PWI, 4PWJ, 4PWK, 4QRF, 4QXV, 4QYA, 4TQ8, 4TQH, 4TQI, 4TQP, 4WNJ, 4WNS, 4WO0, 4YDM, 4YDN, 5BOJ, 4Y9B, 4Y9C, 4Y9E, 4Y9F, 4Y9G, 4TKW, 4TL4, 4TL5, 4TLK, 4TLS, 4TLT, 4TM9, 4TNE, 5AKS, 5AKT, 5AKV, 5AL0, 5AL8, 5CR1, 4TNF, 4TLU, 5AYT, 4TNG, 5EZP, 4D7B, 5A6I, 5E23, 5CNH, 5E4O, 5CN3, 5EN3, 5DWP, 5K1J, 5E4A, 5HJG, 5IHH
Identifiers
Aliases	TTR, CTS, CTS1, HEL111, HsT2651, PALB, TBPA, transthyretin, ATTN
External IDs	OMIM: 176300; MGI: 98865; HomoloGene: 317; GeneCards: TTR; OMA:TTR - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	31,598,833 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	20,807,378 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; beta cell; ; right lobe of liver; ; retinal pigment epithelium; ; body of pancreas; ; gallbladder; ; corpus callosum; ; gonad; ; C1 segment; ; Hypothalamus;
	Top expressed in
	Epithelium of choroid plexus; ; habenula; ; left lobe of liver; ; ciliary body; ; retinal pigment epithelium; ; choroid plexus of fourth ventricle; ; human fetus; ; vestibular membrane of cochlear duct; ; sexually immature organism; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; hormone binding; protein binding; hormone activity; protein heterodimerization activity; thyroid hormone binding;
Cellular component	cytoplasm; extracellular region; extracellular exosome; extracellular space; azurophil granule lumen; protein-containing complex;
Biological process	retinol metabolic process; extracellular matrix organization; retinoid metabolic process; purine nucleobase metabolic process; neutrophil degranulation; thyroid hormone transport; transport; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7276
	22139
	ENSG00000118271
	ENSMUSG00000061808
	P02766
	P07309
	NM_000371
	NM_013697
	NP_000362
	NP_038725
	Wikidata
View/Edit Human	View/Edit Mouse

Transthyretin (TTR or TBPA) is a transport protein in the plasma and cerebrospinal fluid that transports the thyroid hormone thyroxine (T₄) and retinol to the liver. This is how transthyretin gained its name: transports thyroxine and retinol. The liver secretes TTR into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.

TTR was originally called prealbumin (or thyroxine-binding prealbumin) because it migrated faster than albumin on electrophoresis gels. Prealbumin was felt to be a misleading name, it is not a synthetic precursor of albumin. The alternative name TTR was proposed by DeWitt Goodman in 1981.

Human transthyretrin protein is encoded by the TTR gene, which is located on the long arm of chromosome 18, in cytogenetic band 18q12.1.