Triamterene

Triamterene
Clinical data
Trade names	Dyrenium, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682337
Pregnancy; category	AU: C;
Routes of; administration	By mouth
ATC code	C03DB02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	30-70%
Protein binding	67%
Metabolism	hydroxylation to para-hydroxytriamterene
Elimination half-life	1-2 hours, active metabolite 3 hours
Excretion	renal <50%, 21% unchanged
Identifiers
	IUPAC name 6-phenylpteridine-2,4,7-triamine;
CAS Number	396-01-0 ;
PubChem CID	5546;
IUPHAR/BPS	4329;
DrugBank	DB00384 ;
ChemSpider	5345 ;
UNII	WS821Z52LQ;
KEGG	D00386 ;
ChEMBL	ChEMBL585 ;
CompTox Dashboard (EPA)	DTXSID6021373 ;
ECHA InfoCard	100.006.278
Chemical and physical data
Formula	C12H11N7
Molar mass	253.269 g·mol−1
	InChI InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19) ; Key:FNYLWPVRPXGIIP-UHFFFAOYSA-N ;
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Triamterene (traded under names such as Dyrenium and Dytac) is a potassium-sparing diuretic often used in combination with thiazide diuretics for the treatment of high blood pressure or swelling. The combination with hydrochlorothiazide, is known as hydrochlorothiazide/triamterene.