Trimetrexate

Trimetrexate
Clinical data
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a694019
ATC code	P01AX07 (WHO) ;
Pharmacokinetic data
Bioavailability	VD: 20-30 Liters
Metabolism	Oxidative O-demethylation, followed by conjugation with glucuronide or sulfate
Elimination half-life	11 to 12 hours
Identifiers
	IUPAC name 5-methyl-6-[(3,4,5-trimethoxyphenyl) aminomethyl] quinazoline-2,4-diamine;
CAS Number	52128-35-5 ;
PubChem CID	5583;
IUPHAR/BPS	7613;
DrugBank	DB01157 ;
ChemSpider	5381 ;
UNII	UPN4ITI8T4;
KEGG	D06238 ;
ChEMBL	ChEMBL119 ;
CompTox Dashboard (EPA)	DTXSID3023714 ;
Chemical and physical data
Formula	C19H23N5O3
Molar mass	369.425 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n3c1c(c(c(cc1)CNc2cc(OC)c(OC)c(OC)c2)C)c(nc3N)N;
	InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) ; Key:NOYPYLRCIDNJJB-UHFFFAOYSA-N ;
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Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.