Triptolide

Triptolide
Names
	Preferred IUPAC name (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,9bS)-6-Hydroxy-8b-methyl-6a-(propan-2-yl)-3b,4,4a,5a,6,6a,7a,7b,8a,8b,9,10-dodecahydrotris(oxireno)[2′,3′:4b,5;2′′,3′′:6,7;2′′′,3′′′:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Identifiers
CAS Number	38748-32-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:9747;
ChemSpider	97099;
ECHA InfoCard	100.208.723
KEGG	C09204;
PubChem CID	107985;
UNII	19ALD1S53J ;
CompTox Dashboard (EPA)	DTXSID5041144 ;
	InChI InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 Key: DFBIRQPKNDILPW-CIVMWXNOSA-N;
	SMILES CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C;
Properties
Chemical formula	C20H24O6
Molar mass	360.406 g·mol−1
Solubility in water	0.017 mg/mL
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Triptolide is a diterpenoid epoxide which is produced by the thunder god vine, Tripterygium wilfordii. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer, but its physical properties and severe toxicity limit its therapeutic potential. Consequently, a synthetic water-soluble prodrug, minnelide, is being studied clinically instead.

Triptolide is a component of ContraPest, a contraceptive pest control liquid used to reduce rat populations in the United States.