Tryptophan hydroxylase
| tryptophan 5-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
tryptophan 5-monooxygenase monomer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.14.16.4 | ||||||||
| CAS no. | 9037-21-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TPH1 | ||||||
| Alt. symbols | TPRH, TPH | ||||||
| NCBI gene | 7166 | ||||||
| HGNC | 12008 | ||||||
| OMIM | 191060 | ||||||
| PDB | 1MLW | ||||||
| RefSeq | NM_004179 | ||||||
| UniProt | P17752 | ||||||
| Other data | |||||||
| EC number | 1.14.16.4 | ||||||
| Locus | Chr. 11 p15.3-p14 | ||||||
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| tryptophan hydroxylase 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TPH2 | ||||||
| NCBI gene | 121278 | ||||||
| HGNC | 20692 | ||||||
| OMIM | 607478 | ||||||
| RefSeq | NM_173353 | ||||||
| UniProt | Q8IWU9 | ||||||
| Other data | |||||||
| Locus | Chr. 12 q15 | ||||||
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Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. TPH catalyzes the following chemical reaction
- L-tryptophan + tetrahydrobiopterin + O2 5-Hydroxytryptophan + dihydrobiopterin + H2O
