Tuftelin

TUFT1
Identifiers
Aliases	TUFT1, entrez:7286, tuftelin 1
External IDs	OMIM: 600087; MGI: 109572; HomoloGene: 7985; GeneCards: TUFT1; OMA:TUFT1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,583,583 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,566,179 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; pancreatic ductal cell; ; skin of thigh; ; hair follicle; ; skin of arm; ; skin of hip; ; gingival epithelium; ; skin of abdomen; ; buccal mucosa cell; ; human penis;
	Top expressed in
	lip; ; skin of external ear; ; esophagus; ; retinal pigment epithelium; ; epidermis; ; hair follicle; ; gastrula; ; corneal stroma; ; decidua; ; skin of back;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of tooth enamel; protein binding;
Cellular component	cytoplasm; extracellular region; intracellular anatomical structure;
Biological process	biomineral tissue development; bone mineralization; odontogenesis; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7286
	22156
	ENSG00000143367
	ENSMUSG00000005968
	Q9NNX1
	O08970
	NM_001126337; NM_001301317; NM_020127
	NM_011656; NM_001293728
	NP_001119809; NP_001288246; NP_064512
	NP_001280657; NP_035786
	Wikidata
View/Edit Human	View/Edit Mouse

Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel. In humans, the tuftelin protein is encoded by the TUFT1 gene. It is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation.