U.S. Route 169
| U.S. 169 highlighted in red | |
| Route information | |
| Auxiliary route of US 69 | |
| Length | 966 mi (1,555 km) | 
| Existed | 1930–present | 
| Major junctions | |
| South end | US 64 at Tulsa, OK | 
| 
 | |
| North end | US 53 near Virginia, MN | 
| Location | |
| Country | United States | 
| States | Oklahoma, Kansas, Missouri, Iowa, Minnesota | 
| Highway system | |
U.S. Route 169 (US 169) is a north-south U.S highway that currently runs for 966 miles (1,555 km) from the city of Virginia, Minnesota, to Tulsa, Oklahoma, at Memorial Drive.