U.S. Route 17 Alternate
| Route of US 17 Alt. in South Carolina highlighted in red | |
| Route information | |
| Auxiliary route of US 17 | |
| Maintained by SCDOT | |
| Length | 123.900 mi (199.398 km) | 
| Existed | 1951–present | 
| Major junctions | |
| South end | US 17 / US 21 near Pocotaligo | 
| 
 | |
| North end | US 17 / US 701 in Georgetown | 
| Location | |
| Country | United States | 
| State | South Carolina | 
| Counties | Beaufort, Hampton, Colleton, Dorchester, Berkeley, Williamsburg, Georgetown | 
| Highway system | |
U.S. Highway 17 Alternate (US 17 Alt.) is a 123.9-mile (199.4 km) alternate route of US 17 in South Carolina that travels between Pocotaligo and Georgetown. It has been four-laned in various segments since 1970.